Les E. Silberstein
 Les E. SilbersteinChildren's Hospital Boston
Harvard Medical School
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Research Summary
The overall theme of Dr. Silbersteins research laboratory pertains to the role(s) of chemokines in the bone marrow environment. Using B lineage differentiating bone marrow cells as a model, the laboratory wishes to define the molecular signaling pathwaysof the CXCL12/CXCR4 chemokine axis. Although this axis appears to play a major role in hematopoietic progenitor homing/engraftment to the bone marrow as well as retention in the bone marrow for normal hematopoietic development, the mechanisms by which these processes occur remain largely unknown. By better understanding the molecular signaling pathways of the CXCL12/CXCR4 axis, the laboratory hopes to devise strategies to improve stem/progenitor cell engraftment following transplant. Laboratory methods include both in vitro and in vivo intravital microscopy of human cells and gene targeted animal models. Dr. Silberstein is the Director of the Joint Program in Transfusion Medicine, Program Leader for Cell Therapy in the Harvard Stem Cell Institute and Director of the Center for Human Cell Therapy. Through these activities, he brings together Transfusion Medicine-related educational, research and clinical activities of the major Harvard Medical School affiliated institutions in Boston.
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Bio-Sketch
Medical School:
1977 MD, University of Leiden, The Netherlands
Graduate Medical Education :
1977-1978 Intern in Internal Medicine, Georgetown University
Medical Division, Washington, DC
1978-1980 Resident in Internal Medicine, St. Francis Hospital and
Meidcal Center, Hartford, CT
1980-1981 Clinical Fellowship in Hematology/Oncology, Dept of
Medicine, Tufts-New Eng Med Ctr, Boston, MA
1981-1983 Fellowship in Blood Bank, Tufts-New England Medical
Center, Boston, MA
Certification:
1980 American Board of Internal Medicine
1982 American Board of Internal Medicine (Hematology)
1983 American Board of Pathology (Blood Banking)
A. PROFESSIONAL ACTIVITIES AND HONORS
Positions and Employment:
1977 - 1978 Internship: Internal Medicine, Georgetown University Medical Division, D.C. General Hospital, Washington, D.C. 20003
1978 - 1980 Residency: Internal Medicine, St. Francis Hospital and Medical Center, Hartford, Connecticut 06105
1980 - 1981 Clinical Fellowship: Hematology/Oncology, Department of Medicine, Tufts-New England Medical Center Hospital, Boston, Massachusetts 02111
1981 - 1983 Fellowship: Blood Bank, Hematology/Oncology, Tufts-New England Medical Center Hospital, Boston, Massachusetts 02111
1983 - 1987 Assistant Professor, Departments of Pathology and Laboratory Medicine and Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104
1987 - 1994 Associate Professor, Departments of Pathology and Laboratory Medicine and Medicine University of Pennsylvania, Philadelphia, Pennsylvania 19104
1994 - 2000 Professor/Blood Bank Director, Departments of Pathology and Laboratory Medicine and Medicine University of Pennsylvania/Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania 19104
2000 - Chief of the Joint Program in Transfusion Medicine and Biology, Children's Hospital, Dana-Farber Cancer Institute, and Brigham and Womens Hospital/Harvard Medical School, Boston, Massachusetts 02115
2000- Senior Investigator, Center for Blood Research Institute for Biomedical Research/Harvard Medical School, Boston, Massachusetts, 02115
2004-Director, Center for Human Cell Therapy, Center for Blood Research Institute for Biomedical Research, Boston, Massachusetts, 02115
Honors:
1980 -1982 American Cancer Society Fellowship Award
1992- American Society of Clinical Investigation
2000- Henry Kunkel Society, Rockefeller University
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